Metabolic reprograming of anti-tumor immunity
نویسندگان
چکیده
منابع مشابه
Metabolic Reprograming in Macrophage Polarization
Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes. Classically activated or M1 macrophages are...
متن کاملO-GlcNAcylation and Metabolic Reprograming in Cancer
Although cancer metabolism has received considerable attention over the past decade, our knowledge on its specifics is still fragmentary. Altered cellular metabolism is one of the most important hallmarks of cancer. Cancer cells exhibit aberrant glucose metabolism characterized by aerobic glycolysis, a phenomenon known as Warburg effect. Accelerated glucose uptake and glycolysis are main charac...
متن کاملPerspectives on Reprograming Cancer-Associated Dendritic Cells for Anti-Tumor Therapies
In recent years, the relevance of the tumor microenvironment (TME) in the progression of cancer has gained considerable attention. It has been shown that the TME is capable of inactivating various components of the immune system responsible for tumor clearance, thus favoring cancer cell growth and tumor metastasis. In particular, effects of the TME on antigen-presenting cells, such as dendritic...
متن کاملThe impact of metabolic stress on anti-tumor immunity in laboratory mice
There is an underappreciated amount of physiological stress placed on laboratory mice including that due to standard, required housing at sub-thermoneutral temperature. This condition results in an increase in metabolism needed to produce heat necessary to maintain body temperature. Since body temperature maintenance is a high priority for survival, we hypothesized that metabolic energy may be ...
متن کاملRUNX3 methylation and anti-tumor immunity.
Altered DNA methylation is a hallmark of cancer genomes and has been advocated as both a marker and mechanism of the malignant phenotype. In the conventional view, such alterations include global DNA hypomethylation, linked to aberrant expression of oncogenic driver genes and more localised de novo hypermethylation at ‘CpG-island’ promoters, argued to cause inappropriate silencing of tumor supp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2017
ISSN: 0952-7915
DOI: 10.1016/j.coi.2017.03.011